Skip Nav Destination
Article navigation
Volume 11, Issue 3-6
1994
Review Articles| November 05 2008
Subject Area: Gastroenterology , Surgery
Peter Malfertheiner;
Peter Malfertheiner
Department of Gastroenterology, University Hospital of Magdeburg, Germany
Search for other works by this author on:
This Site
Enrique Domínguez-Muñoz
Enrique Domínguez-Muñoz
Department of Gastroenterology, University Hospital of Magdeburg, Germany
Search for other works by this author on:
This Site
Dig Surg (1994) 11 (3-6): 198–208.
Article history
Published Online:
November 05 2008
Content Tools
- Views Icon Views
- Article contents
- Figures & tables
- Video
- Audio
- Supplementary Data
- Peer Review
- Tools Icon Tools
Cite Icon Cite
- Search Site
Citation
Peter Malfertheiner, Enrique Domínguez-Muñoz; Diagnosis and Staging of Acute Pancreatitis. Dig Surg 31 December 1994; 11 (3-6): 198–208. https://doi.org/10.1159/000172255
Download citation file:
- Ris (Zotero)
- Reference Manager
- EasyBib
- Bookends
- Mendeley
- Papers
- EndNote
- RefWorks
- BibTex
Abstract
Determination of serum pancreatic enzymes remains the gold standard for the diagnosis of acute pancreatitis. Clinical symptoms and signs are of major importance in suspecting the disease, but they are not accurate enough to confirm the diagnosis. The different serum pancreatic enzymes have a similar accuracy in the diagnosis of acute pancreatitis. Total amylase, pancreatic isoamylase and lipase are preferred, since simple, rapid and inexpensive enzymatic methods are commercially available. More expensive and cumbersome methods (e.g. RIA or ELISA for pancreatic elastase) are useful only in special clinical circ*mstances. For early etiological classification of acute pancreatitis serum pancreatic enzymes and even different enzyme ratios are not reliable. For this purpose, determination of AST, bilirubin and alkaline phosphatase may make it possible to distinguish between biliary and nonbiliary origin of the disease. Ultrasonography and computed tomography provide very valuable information regarding not only etiology but also local complications of acute pancreatitis. Once the diagnosis of acute pancreatitis has been established, prognostic classification of the disease is required for adequate monitoring and treatment. Clinical symptoms and signs do not allow early assessment of the prognosis of acute pancreatitis. Multivariate scoring systems are sensitive but not sufficiently specific for the identification of severe pancreatitis. Among several biochemical markers commercially available for the assessment of severity, C-reactive protein and PMN-elastase appear to be the most valuable. These markers allow a proper selection of patients who need further investigation by contrast-enhanced CT (the gold standard for detection of pancreatic necrosis).
Keywords:
Acute pancreatitis, Diagnosis, Prognosis, Pancreatic enzymes, Computed tomography, Ultrasonography, Inflammatory mediators
This content is only available via PDF.
© 1994 S. Karger AG, Basel
1994
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisem*nts or/and product references in the publication is not a warranty, endorsem*nt, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisem*nts.
You do not currently have access to this content.
Sign in
Don't already have an account? Register
Individual Login
LOGIN TO MY KARGER
Institutional Login
- Access via Shibboleth and OpenAthens
- Access via username and password
Digital Version
Pay-Per-View Access
$39.00
BUY THIS Article
1 Karger Article Bundle Token
$150
Buy Token
Rental
This article is also available for rental through DeepDyve. 
18 Views
6 Crossref
View Metrics
Email alerts
Online First Alert
Latest Issue Alert
Close Modal
Citing articles via
Google Scholar
CrossRef (6)
- Latest
- Most Read
- Most Cited
N3 disease in esophageal cancer: results from a nationwide registry
Conventional excisional haemorrhoidectomy versus transanal haemorrhoidal dearterialization for haemorrhoids - a systematic review and meta-analysis
Information needs in patients with potentially curable gastro-esophageal cancer
Albumin–Lymphocyte–Globulin–C-Reactive Protein Index as a Novel Prognostic Biomarker for Hepatocellular Carcinoma After Hepatectomy
Lymphocyte-to-Monocyte Ratio Predicts Survival for Intraductal Papillary Mucinous Neoplasm with Associated Invasive Carcinoma of the Pancreas: Results from a High-Volume Center
Suggested Reading
Diagnosis of Acute Pancreatitis
Eur Surg Res (April,2008)
Effects of Octreotide Pretreatment in Experimental Acute Pancreatitis
Pancreatology (May,2003)
Early Diagnosis and Classification in Acute Pancreatitis: A Comparison of Clinical Outcome with Findings at Computed Tomography and Ranson’s Prognostic Signs
Digestion (February,2009)
Magnetic Resonance Imaging in Detecting Acute Oedematous and Haemorrhagic Pancreatitis: An Experimental Study in Pigs
Eur Surg Res (April,2008)
