Introduction:
The aim of the study was to undertake a systematic review and meta-analysis of prospective studies to determine the effect of magnesium (Mg) supplementation on C-reactive protein (CRP). Design: Systematic review and meta-analysis of randomised controlled trials (RCTs).
Material and methods:
Data sources: PubMed-Medline, Web of Science, Cochrane Database, and Google Scholar databases were searched (up until December 2016). Eligibility criteria: Randomized controlled trials evaluating the impact of Mg supplementation on CRP. We used random effects models meta-analysis for quantitative data synthesis. For sensitivity analysis was used the leave-one-out method. Heterogeneity was quantitatively assessed using the I2 index. Main outcome: Level of CRP after Mg supplementation.
Results:
From a total of 96 entries identified via searches, eight studies were included in the final selection. The meta-analysis indicated a significant reduction in serum CRP concentrations following Mg supplementation (weighted mean difference (WMD) –1.33 mg/l; 95% CI: –2.63 to –0.02, heterogeneity p < 0.123; I2 = 29.1%). The WMD for interleukin 6 was –0.16 pg/dl (95% CI: –3.52 to 3.26, heterogeneity p = 0.802; I2 = 2.3%), and 0.61 mg/dl (95% CI: –2.72 to 1.48, p = 0.182, heterogeneity p = 0.742; I2 = 6.1%) for fasting blood glucose. These findings were robust in sensitivity analyses. Random-effects meta-regression revealed that changes in serum CRP levels were independent of the dosage of Mg supplementation (slope: –0.004; 95% CI: –0.03, 0.02; p = 0.720) or duration of follow-up (slope: –0.06; 95% CI: –0.37, 0.24; p = 0.681).
Conclusions:
This meta-analysis suggests that Mg supplementation significantly reduces serum CRP level. RCTs with a larger sample size and a longer follow-up period should be considered for future investigations to give an unequivocal answer.
FAQs
In meta-analysis, Mg supplementation significantly decreased serum C reactive protein (CRP) and increased nitric oxide (NO) levels.
Can magnesium supplements affect your CRP level? ›
This meta-analysis suggests that Mg supplementation significantly reduces serum CRP level.
Is dietary magnesium intake inversely associated with serum C-reactive protein levels meta-analysis and systematic review? ›
This meta-analysis and systematic review indicate that dietary Mg intake is significantly and inversely associated with serum CRP levels. The potential beneficial effect of Mg intake on chronic diseases may be, at least in part, explained by inhibiting inflammation.
What supplements can affect CRP levels? ›
The cross-sectional relationship between vitamin C and high-sensitivity C-reactive protein levels: insights from NHANES database. Background: Ascorbic acid or vitamin C has antioxidant and anti-inflammatory properties that may impact markers of inflammation like C-reactive protein (CRP).
Does magnesium help with inflammation in the body? ›
Magnesium has been shown to help fight inflammation by reducing markers such as CRP and interleukin-6.
What can cause a false high CRP? ›
Recent injury or illness can falsely elevate levels, particularly when using this test for cardiac risk stratification. Magnesium supplementation also can decrease CRP levels. As mentioned above, mild elevations in CRP can be seen without any systemic or inflammatory disease.
Why is my CRP so high no reason? ›
If your CRP test results reveal that you have high levels of CRP, it doesn't necessarily mean that you have a medical condition that needs treatment, especially if they're only slightly elevated. Several factors, such as smoking, recent injury and certain health conditions, can raise your CRP levels.
How does magnesium affect protein? ›
Magnesium is a cofactor in more than 300 enzyme systems that regulate diverse biochemical reactions in the body, including protein synthesis, muscle and nerve function, blood glucose control, and blood pressure regulation [1-3]. Magnesium is required for energy production, oxidative phosphorylation, and glycolysis.
What are the relationships between magnesium and protein concentrations in serum? ›
Albumin and magnesium concentrations are linearly related at high and low albumin concentrations; within the reference interval, however, the magnesium concentration is independent of the albumin concentration.
What body system does magnesium affect the most? ›
Magnesium is needed for more than 300 biochemical reactions in the body. It helps to maintain normal nerve and muscle function, supports a healthy immune system, keeps the heartbeat steady, and helps bones remain strong. It also helps adjust blood glucose levels.
Increase Your Specific Vitamin Consumption: Certain vitamins and minerals, including vitamin D and omega-3 fatty acids, have been related to decreased CRP levels. Consider adding supplements or foods high in these nutrients to your diet.
What is the #1 best vitamin for chronic inflammation? ›
Best vitamins and supplements for chronic inflammation
- Omega-3 Fatty Acids. ...
- Curcumin (Turmeric) ...
- Green Tea Extract. ...
- Ginger. ...
- Boswellia (Indian Frankincense) ...
- Vitamin D. ...
- Probiotics.
CoQ10 supplementation significantly reduced CRP levels (ESSMD = −0.39; 95% CI: 0.77, −0.01, p = 0.042) (Figure 4A). Nevertheless, there was no significant between-study heterogeneity (I2 = 38.5%, p = 0.197).
What autoimmune disease is associated with magnesium deficiency? ›
Research indicates a strong link between low magnesium levels and a number of autoimmune diseases ranging from Alzheimer's to Diabetes. In fact, there is a significant correlation between increasing dietary magnesium to reduce the severity of rheumatoid and psoriatic arthritis.
Who should not take magnesium? ›
Since magnesium is excreted by the kidneys, people with heart or kidney disease should not take magnesium supplements except under their doctors' supervision.
What vitamins reduce CRP? ›
Vitamin C treatment reduces elevated C-reactive protein.
What raises CRP levels? ›
The level of CRP rises when there is inflammation in the body. It is one of a group of proteins, called acute phase reactants that go up in response to inflammation. The levels of acute phase reactants increase in response to certain inflammatory proteins called cytokines.
What medications can affect a CRP test? ›
Some medications, including nonsteroidal anti-inflammatory drugs and statins, can impact CRP levels. Magnesium supplements also can affect your CRP level. For this reason, tell your doctor about any medications or supplements you take and ask whether you should adjust your medications before the test.
Can the pill cause high CRP? ›
Hormonal contraceptive users have been shown in past research to have higher levels of C-reactive protein (CRP), which is a marker of systemic inflammation, compared to non-users.
