PRP for Erectile Dysfunction: Research, Benefits, and Risks (2024)

Platelet-rich plasma (PRP) is a component of blood that’s thought to promote healing and tissue generation. PRP therapy is used to treat tendon or muscle injuries, stimulate hair growth, and speed recovery from surgery.

It’s also used as an experimental or alternative treatment option for:

  • erectile dysfunction (ED)
  • Peyronie’s disease
  • penis enlargement
  • sexual performance

There’s currently little research on the effectiveness of PRP for ED. In this article, we’re going to break down what scientists have found so far. We’ll also look at alternative treatment options and potential side effects of PRP therapy.

Your blood is made of four different components: red blood cells, white blood cells, plasma, and platelets.

Plasma is the liquid part of your blood and makes up about half of its volume. Platelets are critical for helping your blood clot after an injury. They also contain proteins called growth factors that help speed up healing.

The theoretical benefit of PRP for ED is to make the tissue and blood vessels in the penis healthier.

To prepare PRP, a medical professional takes a small sample of your blood and spins it in a machine called a centrifuge. The centrifuge separates the plasma and platelets from the other parts of your blood.

The resulting PRP mixture has a much higher concentration of platelets than regular blood. Once the PRP is developed, it’s injected into your penis. This is called the Priapus Shot, or P-Shot.

The P-Shot is a quick procedure, and you’ll likely be able to leave the clinic in about an hour. You also don’t have to do anything to prepare in advance for the procedure.

Many clinics offering PRP for ED claim that it’s effective, but there’s limited scientific evidence to support their claims. Using PRP for ED is experimental, and its effectiveness is still under review.

A 2020 review looked at all the research available to date on PRP therapy for male sexual dysfunction. The review looked at three animal studies and two human studies for ED. The studies didn’t report any major adverse reactions to PRP therapy.

The researchers concluded that PRP has the potential to be a useful treatment option for ED. However, it’s important to keep in mind that the studies had small sample sizes, and there weren’t adequate comparison groups.

More research is needed to understand the benefits of PRP treatment. The current evidence is mostly anecdotal.

At this time, it isn’t clear if undergoing PRP therapy will help improve symptoms of ED. Traditional treatment options might be a better alternative until more research is available.

Many people with ED have success with traditional treatment options, which usually target the underlying cause of ED. Your doctor can evaluate you for potential causes of ED, such as heart disease, high cholesterol, or diabetes, and recommend the best treatment option for you.

Common ED treatments include:

  • Medications. ED medications allow the blood vessels in the penis to relax and increase blood flow.
  • Lifestyle changes. Becoming more physically active, eating a healthier diet, and quitting smoking all have the potential to improve ED.
  • Talk therapy. Talk therapies might help improve ED if it’s a result of psychological causes, such as anxiety, stress, or relationship problems.
  • Targeting underlying conditions. ED is often caused by an underlying condition, such as high blood pressure, obesity, and heart disease. Treating these conditions has the potential to improve erection quality.

Few insurance plans currently cover PRP because it’s still considered an experimental treatment. The cost of the P-Shot can range widely among clinics. According to the Hormone Zone, the P-Shot procedure costs about $1,900. However, some clinics may charge up to $2,200 for treatment.

According to the 2018 Plastic Surgery Statistics Report, the average doctor fee for a PRP procedure was $683, not including facility and instrument cost.

If you’re interested in having PRP treatment for ED, talk to your doctor. They can answer your questions about PRP and refer you to a specialist who performs the treatment. Globally, there are at least 683 registered clinics that can administer PRP for ED.

PRP is usually performed by a doctor or surgeon. However, laws on who can perform the treatment may vary between countries.

When looking for somebody to perform PRP, check their medical credentials to make sure they’re licensed by a medical board before you make an appointment.

If possible, you may also want to speak to one of their previous clients to see if they were happy with their results.

The 2020 review mentioned earlier found no major adverse effects in the study participants. However, researchers can’t say whether or not PRP is a safe treatment for ED until more research comes out.

As of now, there have been few clinical trials, and the sample sizes have been too small to make any conclusions.

PRP is unlikely to cause an allergic reaction since the substance being injected is coming from your body. However, as with any type of injection, there’s always a risk of complications, such as:

  • infection
  • nerve damage
  • pain, including pain at the injection site
  • tissue damage
  • bruising

PRP therapy is still an experimental treatment. At this time, it isn’t clear if PRP can help treat ED. The procedure is relatively expensive and isn’t covered by most insurance companies.

Early research looks promising, but until studies with large sample sizes and control groups come out, you may want to stick with traditional ED treatments.

If you’re having trouble getting an erection, it’s a good idea to talk to your doctor. They can test you for underlying medical conditions that may be causing ED and recommend an appropriate treatment.

PRP for Erectile Dysfunction: Research, Benefits, and Risks (2024)

FAQs

What is the success rate of PRP for erectile dysfunction? ›

They found that at 6 months, 69% of men in the PRP group vs. 27% of the men in the placebo group achieved MCID (risk difference of 42%, P < 0.001). Statistically significant results were also achieved at the 1- and 3-month follow-up period.

Can PRP help with erectile dysfunction? ›

Many clinics offering PRP for ED claim that it's effective, but there's limited scientific evidence to support their claims. Using PRP for ED is experimental, and its effectiveness is still under review.

What is the downside of PRP? ›

PRP Therapy Risks and Side Effects

After the procedure, you may experience some soreness and bruising at the injection site. Because PRP injections are made up of your own cells and plasma, the risk of an allergic reaction is much lower than with other injectable medications like corticosteroids.

What are the risks of the P-Shot? ›

The P-Shot uses platelet-rich plasma to possibly treat penile-related conditions. There isn't enough research on the P-Shot to verify its benefits or determine how or why it works. Risks include bruising, swelling and discoloration.

How long does PRP for ED last? ›

The results of this treatment last for far longer than a measly day. A single treatment with this injection can produce results that last between 12 and 18 months at a time. That's over a year of improved sexual health and erectile function.

How long will PRP results last? ›

Since each person and their skin is individual, how long a patient can expect to enjoy their results can vary. In general, many patients can enjoy the benefits from their PRP facelift for up to two years.

Why is PRP not recommended? ›

While PRP is considered safe for most people, it's not recommended for anyone who has one of the following medical conditions: Hepatitis C. HIV or AIDS. Any type of blood cancer.

Why is PRP controversial? ›

To date, there has been no conclusive evidence of its effectiveness, or standardization of treatment. As a result, some health bodies and organizations strongly recommend against the use of PRP treatments.

Who is not a good candidate for PRP? ›

If you have cardiovascular disease or another condition that requires you to take blood thinners, you may not be a candidate for PRP therapy.

Does the p Shot increase size? ›

How Does the P-Shot Increase Size? For some men, the P-Shot can increase their overall size. This happens because the PRP triggers the formation of healthy and strong tissue. In addition to the development of new erectile tissue, you will also enjoy new blood flow to the penis.

How much does the P Shot cost? ›

What is the Cost of P Shot? The exact cost for a P-Shot can be anywhere from several hundred dollars to a few thousand dollars per session. That being said, the P-Shot treatment is one of the more cost-effective solutions compared to other ED treatments since it's an outpatient procedure.

Is p Shot FDA approved? ›

The Priapus shot is an FDA-approved treatment for erectile dysfunction (ED). Erectile dysfunction affects millions of men in the United States.

What is the best injection for erectile dysfunction? ›

The 3 most commonly used medications for injection therapy are Trimix, Bimix, and papaverine. Most men begin injection therapy with Trimix, which is a mixture of 3 ingredients: alprostadil, phentolamine, and papaverine.

Can you take Viagra after PRP injection? ›

Viagra, Cialis, Levitra and similar drugs may be used in conjunction with PRP injections, but are often not needed.

Does PRP work permanently? ›

Unfortunately, PRP can't cure hair loss. It can only temporarily restore your follicles' ability to regrow hair. So, it can't be considered a permanent solution.

How long does PRP release growth factors? ›

Results. The highest reported growth factor released from platelet concentrates was PDGF-AA followed by PDGF-BB, TGFB1, VEGF, and PDGF-AB. In general, following 15–60 min incubation, PRP released significantly higher growth factors when compared to PRF and A-PRF.

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