Reactive arthritis-Reactive arthritis - Diagnosis & treatment - Mayo Clinic (2024)

Diagnosis

During the physical exam, your doctor is likely to check your joints for swelling, warmth and tenderness, and test range of motion in your spine and affected joints. Your doctor might also check your eyes for inflammation and your skin for rashes.

Blood tests

Your doctor might recommend that a sample of your blood be tested for:

  • Evidence of past or current infection
  • Signs of inflammation
  • Antibodies associated with other types of arthritis
  • A genetic marker linked to reactive arthritis

Joint fluid tests

Your doctor might use a needle to withdraw a sample of fluid from within an affected joint. This fluid will be tested for:

  • White blood cell count. An increased number of white blood cells might indicate inflammation or an infection.
  • Infections. Bacteria in your joint fluid might indicate septic arthritis, which can result in severe joint damage.
  • Crystals. Uric acid crystals in your joint fluid might indicate gout. This very painful type of arthritis often affects the big toe.

Imaging tests

X-rays of your low back, pelvis and joints can indicate whether you have any of the characteristic signs of reactive arthritis. X-rays can also rule out other types of arthritis.

Treatment

The goal of treatment is to manage your symptoms and treat an infection that could still be present.

Medications

If your reactive arthritis was triggered by a bacterial infection, your doctor might prescribe an antibiotic if there is evidence of persistent infection. Which antibiotic you take depends on the bacteria that are present.

Signs and symptoms of reactive arthritis may be eased with:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs). Prescription nonsteroidal anti-inflammatory drugs (NSAIDs), such as indomethacin (Indocin), can relieve the inflammation and pain of reactive arthritis.
  • Steroids. A steroid injection into affected joints can reduce inflammation and allow you to return to your usual activity level. Steroid eye drops may be used for eye symptoms, and steroid creams might be used for skin rashes.
  • Rheumatoid arthritis drugs. Limited evidence suggests that medications such as sulfasalazine (Azulfidine), methotrexate (Trexall) or etanercept (Enbrel) can relieve pain and stiffness for some people with reactive arthritis.

Physical therapy

A physical therapist can provide you with targeted exercises for your joints and muscles. Strengthening exercises increase the joint's support by developing the muscles around the affected joints. Range-of-motion exercises can increase your joints' flexibility and reduce stiffness.

Preparing for your appointment

You'll likely start by seeing your primary care provider, who might refer you to a doctor who specializes in arthritis (rheumatologist) for further evaluation.

What you can do

When you make the appointment, ask if there's anything you need to do in advance, such as fasting before having a specific test. Make a list of:

  • Your symptoms, including any that seem unrelated to the reason for your appointment
  • Key personal information, including your medical history and your family's medical history
  • All medications, vitamins or other supplements you take, including doses
  • Questions to ask the doctor

Take a family member or friend along, if possible, to help you remember the information you're given. For reactive arthritis, basic questions to ask your doctor include:

  • What is likely causing my symptoms or condition?
  • What are other possible causes?
  • What tests do I need?
  • What treatment approach do you recommend?
  • How soon do you expect my symptoms to improve with treatment?
  • Is there anything I can do now to help relieve my joint pain?
  • Am I at risk of long-term complications from this condition?
  • I have these other health conditions. How can I best manage them together?

Don't hesitate to ask other questions.

What to expect from your doctor

Your doctor is likely to ask you a number of questions, such as:

  • When did your symptoms begin?
  • Have they been continuous or occasional?
  • How severe are your symptoms?
  • What, if anything, seems to improve your symptoms?
  • What, if anything, appears to worsen your symptoms?
  • Have you had a recent infection?
Reactive arthritis-Reactive arthritis - Diagnosis & treatment - Mayo Clinic (2024)

FAQs

What triggers reactive arthritis? ›

Reactive arthritis is a type of arthritis caused by an infection. It may be caused by Chlamydia trachomatis, salmonella, or another infection. The condition may cause arthritis symptoms, such as joint pain and inflammation. It may also cause symptoms in the urinary tract and eyes.

What is the best medication for reactive arthritis? ›

Prescription nonsteroidal anti-inflammatory drugs (NSAIDs), such as indomethacin (Indocin), can relieve the inflammation and pain of reactive arthritis. Steroids. A steroid injection into affected joints can reduce inflammation and allow you to return to your usual activity level.

Can reactive arthritis go away? ›

Reactive arthritis symptoms usually go away within three to six months after you start treatment. But it can become a chronic illness for 20% of people who have the condition.

What is the prognosis for reactive arthritis? ›

Most people will make a full recovery within a year, but a small number of people experience long-term joint problems. Treatment usually focuses on: clearing the original infection that triggered the reactive arthritis – usually using antibiotics in the case of sexually transmitted infections (STIs)

What aggravates reactive arthritis? ›

Reactive arthritis is triggered by an infection—frequently a sexually transmitted or food-borne bacterial infection—but it is separate from the infection and typically sets in after the infection has cleared.

What organs does reactive arthritis affect? ›

Overview. Reactive arthritis is joint pain and swelling triggered by an infection in another part of the body — most often the intestines, genitals or urinary tract.

What foods help reactive arthritis? ›

Tips for managing your diet if you have arthritis

include a variety of fruit and vegetables, protein foods, dairy, nuts, pulses, cereals and grains. This will help to maintain general good health and a healthy weight.

Is walking good for reactive arthritis? ›

Exercise reduces joint pain and helps fight tiredness. Of course, when joints are stiff and painful, the thought of walking around the block or swimming a few laps might seem like too much. There's no need to run a marathon or swim for miles. Even moderate exercise can ease pain and help you stay at a healthy weight.

What is the new treatment for reactive arthritis? ›

Etanercept has been shown to reduce inflammation, improve symptoms and reduce joint damage in rheumatoid arthritis, and to be effective in the treatment of ReA and undifferentiated arthritis [25]. In a 6-month open clinical trial, 16 patients with ReA or undifferentiated arthritis were treated with etanercept [39].

Is reactive arthritis a disability? ›

Arthritis causes more than just pain. It's a leading cause of disability. A disability is a condition that limits your typical movements, senses, or activities.

How painful is reactive arthritis? ›

Reactive arthritis causes you to have extremely painful, swollen joints and can make you feel very tired. It can affect your joints after you've had an infection somewhere else in your body, such as a tummy bug, diarrhoea (die-a-ree-ah), or a throat infection.

Is reactive arthritis an autoimmune disease? ›

Reactive Arthritis is a form of autoimmune arthritis or joint inflammation, that occurs as a “reaction” to an infection elsewhere in the body. Inflammation is a characteristic reaction of tissues to injury or disease and is marked by swelling, redness, heat, and pain.

What is the most likely cause of reactive arthritis? ›

Typically, reactive arthritis is caused by a sexually transmitted infection (STI), such as chlamydia, or an infection of the bowel, such as food poisoning. You may also develop reactive arthritis if you, or someone close to you, has recently had glandular fever or slapped cheek syndrome.

How to reverse reactive arthritis? ›

There is no cure for reactive arthritis. Medical care aims to manage the symptoms until you get better. Treatment may include: antibiotics – to destroy the bacteria that caused the initial infection.

Does reactive arthritis show up on blood tests? ›

HLA-B27. This blood test looks for the presence of HLA-B27, a genetic risk factor for reactive arthritis. Having this marker is consistent with having reactive arthritis, but it is not definitive—people who test negative can still have reactive arthritis, and not everyone who tests positive has the condition.

What is reactive arthritis commonly associated with? ›

Bacterial infection of the urinary tract or intestines is the most common cause of reactive arthritis. The most common bacterium associated with reactive arthritis is Chlamydia trachomatis (which is responsible for chlamydia infections).

What causes arthritis inflammation flare ups? ›

Injury to your skin. Certain medications. Bacterial infections, specifically strep throat. Other possible triggers: allergies, diet, alcohol intake, smoking and weather changes.

What mimics reactive arthritis? ›

Lupus and Scleroderma

Systemic lupus erythematosus (lupus) and scleroderma are two autoimmune diseases that can mimic rheumatoid arthritis. Autoimmune diseases are those in which the body's immune system attacks its own cells and tissues.

Can reactive arthritis be triggered by stress? ›

The longer you're exposed to stress, the more destructive the inflammation can become. In a PLoS One study, people with RA identified stress as a trigger for disease flare-ups. Arthritis symptoms contribute to stress, especially when they're unrelenting. Constant pain, fatigue, and poor sleep create a vicious cycle.

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